This book, a joint publication of the Institute of Physics Publishing and Oxford University Press, is the third in a series of three works that form part of the Oxford/IOP Computational Intelligence Library project. The other two works are the Handbook of Neural Computation and the Handbook of Evolutionary Computation. Each of the three handbooks is available in loose-leaf print form, as well as in an electronic version that combines both CD-ROM and on-line (World Wide Web) access to the contents. (...) In each case, regularly published supplements will be available on a subscription basis. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Ideas 63.2 (2002) 185-206 [Access article in PDF] Machiavelli's Sketches of Francesco Valori and the Reconstruction of Florentine History Mark Jurdjevic... As for the lies of these citizens of Carpi, I can surpass them all, because it has been a long time since I became a doctor of that art... for some time now I have never said what I believed and never believed (...) what I said; and if indeed I do sometimes tell the truth, I hide it behind so many lies that it is hard to find.... Niccolò Machiavelli to Francesco Guicciardini, Carpi, 17 May 1521. 1Is Machiavelli a reliable source for Florentine history? This article addresses that question by focusing on a remarkable discrepancy in Machiavelli's writing: the Florentine secretary's contradictory interpretations of Francesco di Filippo Valori, a major figure in the post-Medicean republican regime and one of the leaders of the Savonarolan movement. In the Discourses, Machiavelli described Valori as an ambitious politician whose quasi-princely power engendered dangerous factional violence. Several years later, in The Natures of Florentine Men, one of the few texts from Machiavelli's literary corpus that has yet to receive any sustained analysis, Machiavelli described Valori as a republican patriot who consistently sought the common good and upheld the republic's laws. Both assessments were written over a decade after Valori's murder (1498). [End Page 185]What caused Machiavelli to alter his initial interpretation? Were both accounts part of a larger single interpretation of the Florentine statesman? If not, which portrait more faithfully conveyed the nature of Francesco Valori's career and its effect upon Florentine political life and what did Machiavelli hope to achieve by the other portrait? Finally, why did Machiavelli praise a man so directly associated with Savonarola and the political party that had excluded Machiavelli from office before 1498? Machiavelli's reputation as an opponent of Savonarola was the cause of his rejection for an office in the Second Chancery in February 1497, during Valori's term as Gonfaloniere di giustizia. It was also a likely cause of his more spectacular success in April 1498, immediately following the downfall of Savonarola and Valori. 2This article examines the political circumstances surrounding the composition of The Natures of Florentine Men, Machiavelli's ties to the Valori family, and contemporary accounts of Valori's personality and career. It argues that The Natures are the preliminary sketches of the unwritten ninth book of the Florentine Histories and that Machiavelli, writing in a Florence of renewed Medici power, rewrote Valori's role in recent history to obscure his own ties to the principal statesmen of the Soderini regime. In particular, arguing from a different set of sources, it confirms Felix Gilbert's cautious and often-forgotten reminder about the impact of politics and political survival on the pioneering historical literature of early sixteenth-century Florence: that Machiavelli and Guicciardini "frequently had political purposes when discussing historical events and thus consciously constructed a historical myth." 3The Valori family played a prominent role in the political and cultural life of Quattrocento Florence. The family had been allied with the Medici since Cosimo de' Medici's political ascent in 1434 and Bartolomeo Valori, as a generous patron of neo-Platonic philosophy, became a close friend of Lorenzo de' Medici and Marsilio Ficino. Francesco, however, dramatically realigned the family's political identity and loyalties along strong anti-Medicean lines. He began his political career as a successful participant in the Medici party, receiving numerous offices and distinctions, including election as Gonfaloniere di giustizia three times (1484, 1489, 1493). When the political tide turned against Piero de' Medici in 1494, however, Valori was among the first ottimati to capitalize on Medici weakness. He participated in the popular revolt against Piero de' Medici and became one of the constitutional founders of the new Republic. His power and ambition became famous, even notorious, after he emerged as one of the most important and powerful political allies (1495-98) of the prophetic friar... (shrink)

Many believe that a citizen who engages in civil disobedience is not exempt from the sanctions that apply to standard law-breaking conduct. Since he is responsible for a deliberate breach of the law, he is also liable to punishment. Focusing on a conception of responsibility as answerability, I argue that a civil disobedient is responsible (i.e. answerable) to his fellows for the charges of wrongdoing, yet he is not liable to punishment merely for breaching the law. To support this claim, (...) I defend an account of political obligation framed in terms of respect for (rather than mere obedience to) the law, and argue that the mere illegality of civil disobedience does not suffice to establish wrongdoing. I then discuss and reject three objections to my argument. (shrink)

The fair-play theory of punishment claims that the state is justified in imposing additional burdens on law-breakers, to remove the unfair advantage the latter have enjoyed by disobeying the law. From this perspective, punishment reestablishes a fair distribution of benefits and burdens among all citizens. In this paper, I object to this view by focusing on the case of civil disobedience. I argue that the mere illegality of this conduct is insufficient to establish the agent’s unfair advantage over his lawabiding (...) fellows, hence the imposition of additional burdens upon him through legal punishment. I articulate a broader account of citizens’ fair-play duties, able to capture disobedience as well as obedience to the law. While claiming that some law-breakers may not be treated as free-riders, I also gesture at the fact that some law-obeying citizens may not be ‘playing fair’: in some cases, a failure to engage in civil disobedience represents a failure to do one’s own part within the cooperative scheme of society. (shrink)

ABSTRACTThis article examines the Trinitarian anthropology inherent in the ‘charism of unity’ that characterizes the Focolare Movement stemming from the mystical experience of Chiara Lubich. After describing the theological cornerstones of this charism―namely the evangelical centrality of the commandment of reciprocal love, the circularity between theology and anthropology and Jesus Forsaken as the Christological key to understanding and achieving unity―the article studies its cultural implications as reflected in the philosophical and theological contribution of Klaus Hemmerle. In dialogue with modern thought, (...) Hemmerle in fact draws from and develops the anthropological meaning of the charism of unity as a feasible way to respond to the most acute challenges of today. (shrink)

El autor plantea que el Estado ha ingresado en una creciente crisis y la sospecha sobre su real “utilidad” para la sociedad, y vincula a este tema el surgimiento de la cuestión del espacio público. Sostiene que un cambio radical se produce a partir de la nueva percepción del territorio, cuando ya no parece posible que el Estado, y por lo tanto el espacio público, pueda ser pensado exclusivamente en términos nacionales. Discute luego la relación espacio público-vida privada, y los (...) nuevos modos de hacer política en este nuevo espacio público. Afirma finalmente que la construcción de un bien común puede ser pensado y diseñado colectivamente. (shrink)

Acts of civil disobedience, which imply the open violation of a legal directive, often result in the forceful imposition of a choice upon others (e.g. blockades). This is sometimes justifiable, within a democracy, in cases of ‘democratic deficit’, namely, when fundamental rights of an oppressed minority are at stake. In this article, I claim that the use of physical force, in a democracy, may also be justified by the rights of (at least some of) the very people upon whom force (...) is applied. Focusing on the nature of civil disobedience as a ‘form of address’, I argue: (1) using physical force to address others in the democratic arena does not entail infringing upon their status as autonomous agents; (2) using physical force to address others in the democratic arena may contribute to the fulfilment of a positive duty to promote the autonomy of (at least some of) those very people upon whom force is applied. This is not a defence of paternalism: I claim that using force against others, in the democratic arena, may be constitutive of a behaviour that treats others with the respect due to their status as autonomous agents. (shrink)

It is still an open question whether or not Civil Disobedience (CD) has to be completely nonviolent. According to Rawls, “any interference with the civil liberties of others tend to obscure the civilly disobedient quality of one's act”. From this Rawls concludes that by no means can CD pose a threath to other individuals' rights. In this paper I challenge Rawls' view, arguing that CD can comprise some degree of violence without losing its “civil” value. However, I specify that violence (...) must not be aimed at seriously injuring, or even killing, other individuals. This would contravene the communicative aspect of CD. The main claim is that what really is important is that the civil disobedients be willing to accept the punishment following their law-breaking behaviour. By doing so, they demonstrate the conscientiousness of their civilly disobedient action. This also shows that they are aiming for future cooperation with the State, and are expecting the State to be sensitive to their concern for the principles of justice. (shrink)

(2000). The Evolutionary challenge for the Enterprise. World Futures: Vol. 55, Challenges of Evolution at the Turn of the Millennium: Part III: The Chllenges of Globalization and Sustainability, pp. 159-171.

Protein aggregation has been studied for at least 3 decades, and many of the principles that regulate this event are relatively well understood. Here, however, we present a different perspective to explain why proteins aggregate: we argue that aggregation may occur as a side‐effect of the lack of one or more natural partners that, under physiologic conditions, would act as chaperones. This would explain why the same surfaces that have evolved for functional purposes are also those that favour aggregation. In (...) the course of reviewing this field, we substantiate our hypothesis with three paradigmatic examples that argue for the generality of our proposal. An obvious corollary of this hypothesis is, of course, that targeting the physiological partners of a protein could be the most direct and specific approach to designing anti‐aggregation molecules. Our analysis may thus inform a different strategy for combating diseases of protein aggregation and misfolding. (shrink)

Jason Brennan has argued that democracy is intrinsically unjust, for it grants voting power to politically incompetent individuals, thus exposing people to an undue risk of harm. He claims democracy should be replaced by epistocracy, i.e., the rule of the knowers. In this paper, I show that his argument fails. First, Brennan mistakes voters’ competence for voters’ trustworthiness. Second, despite Brennan's claim to the contrary, an epistocracy may not reduce people’s exposure to an undue risk of harm. Third, Brennan overlooks (...) the fact that citizens are not equally affected by ‘bad voting.’ Fourth, far from being a defence of libertarian ideals, Brennan's argument supports paternalism. (shrink)

Contrary to what has been asserted or implied by Mach and more recent writers, the law of illumination and the study of photometry were not ignored in the years between Kepler's first enunciation of the former in 1609 and Bouguer's Essai on the latter in 1729. The law of illumination was in fact denied in 1613 by Aguilonius. It was probably rediscovered independently and certainly reformulated in more modern terms by Mersenne and Castelli in 1634, and by Boulliau in 1638. (...) It was again formulated and this time demonstrated empirically by Montanari no later than 1676, and possibly as early as 1634 by Castelli. Although neither the law nor photometry were major concerns before Bouguer, they were not completely neglected either. (shrink)

Derek Parfit’s thesis that identity doesn’t matter in survival has been extensively discussed except for its metaphysical robustness. How can we justify the abandonment of identity in the way Parfit suggests? My argument is the following. Those who want to endorse the thesis that identity doesn’t matter (and, therefore, abandon identity across time) should adopt exdurantism, i.e. a metaphysics according to which the world is composed by temporal parts each existing at a time and according to which there is nothing (...) as a numerically same entity which exists at different times. I show that the metaphysics behind Parfit’s theory is neither compatible with endurantism, according to which object persists by being wholly present at different times, nor with perdurantism, according to which entities are aggregates of temporal and spatial parts. (shrink)

My aim is to defend Winch's view that morality must be autonomous from religion. I defend him from Mounce's criticism, who claims that unless morality is supported by divine law, moral relativism cannot be avoided. Winch considers the Samaritan's behaviour and says (i) that the background of divine law is irrelevant to the parable; (ii) that we do not need divine law to understand the Samaritan's impossibility to ignore the victim; (iii) and that the absolute moral ought requires no external (...) support provided by religion. Winch adds that God cannot make any moral demand on humans, and thus He cannot reward them with salvation or punish them, without turning Himself into a means of moral corruption. All this spells the end of religion at least as far as the relation between God and man's moral and spiritual life is concerned; while relativism is shown to be morally corrupt and internally inconsistent. (shrink)

Central topics pertaining to the current debate in the philosophy of action concern the distinction between practical and theoretical reasoning, and the nature of a conclusion in a process of reasoning. In this debate the reference to the Aristotelian reflection is recurrent. In four passages from his works, that is MA. 7, 701a7-b1, EN. H 5, 1147a24-31, EE. B 11, 1227b23-33 and EN. Г 5, 1112bl1-24, Aristotle explores some important aspects of practical reasoning making a parallel with the logical structures (...) of theoretical reasoning. In particular he finds specific analogies between practical and theoretical syllogism, practical and theoretical necessity, deliberation and analysis, action and demonstration. In spite of its specifications, the activity of reason shows its unity. Aristotle considers and deepens the constitutive ingredients of theoretical reasoning in the contest of practical philosophy. The comparison between practical and theoretical reasoning has consequently an expositive purpose, because it supports Aristotle's treatment of action theory. (shrink)

Proteins are targeted to plastids by N‐terminal transit peptides, which are recognized by protein import complexes in the organelle membranes. Historically, transit peptide properties have been defined from vascular plant sequences, but recent large‐scale genome sequencing from the many plastid‐containing lineages across the tree of life has provided a much broader representation of targeted proteins. This includes the three lineages containing primary plastids (plants and green algae, rhodophytes and glaucophytes) and also the seven major lineages that contain secondary plastids, “secondhand” (...) plastids derived through eukaryotic endosymbiosis. Despite this extensive spread of plastids throughout Eukaryota, an N‐terminal transit peptide has been maintained as an essential plastid‐targeting motif. This article provides the first global comparison of transit peptide composition and summarizes conservation of some features, the loss of an ancestral motif from the green lineages including plants, and modifications to transit peptides that have occurred in secondary and even tertiary plastids. BioEssays 29:1048–1058, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

The Bible and its Rewritings examines some of the most beautiful and intriguing scenes from the Old and New Testament such as the encounter between Abraham and God, and Jesus and Mary Magdalene. The author also investigates the direct or indirect Re-Scriptures of these by writers like Thomas Mann, Chaucer, Shakespeare, T. S. Eliot, Faulkner, Tournier, Joseph Roth, as well as by ancient exegesis, catacomb frescoes, and church paintings.